Active substance: dapoxetine, commonly supplied as dapoxetine hydrochloride. It is sold under brand names such as Priligy in some countries and is available as generic products in other regions.
Brief summary: dapoxetine is a short acting selective serotonin reuptake inhibitor developed specifically for on demand management of premature ejaculation. Unlike daily SSRIs prescribed for depression, dapoxetine is intended to be taken in anticipation of sexual activity rather than every day.
Key point: the purpose of this medicine is to postpone ejaculation and improve control. It is not a treatment for erectile dysfunction. When both erectile problems and premature ejaculation occur together, combined treatments are often considered; see Related Medications and Other paths for common combined approaches.
Common tablet strengths seen outside the United States are 30 mg and 60 mg. Some suppliers may offer nonstandard doses, and higher amounts generally increase the chance of adverse reactions.
Indicators and the mechanism involved
Main approved use: to treat premature ejaculation in adult males by prolonging the time to ejaculation, improving perceived control, and enhancing sexual satisfaction.
Acting the operative mechanism: dapoxetine temporarily increases serotonin activity in the central nervous system, which influences the ejaculatory reflex and can delay ejaculation timing.
How to apply
- Only use dapoxetine under the direction of a qualified healthcare professional.
- Swallow tablets with water; do not crush or chew unless instructed by a clinician.
- Take the tablet on an as needed basis, typically 1 to 3 hours before sexual activity. Do not take two or more doses in a single 24 hour period.
- Avoid consuming alcohol around the time you take the medicine because alcohol can increase dizziness, sedation, and fainting risk.
If you need guidance on timing or combination with other medicines, refer to Substances and Drugs: Interaction Effects and speak with your clinician or pharmacist.
Dosage levels to choose from
Typical dosage schedule strategy where dapoxetine is available: begin with 30 mg taken when needed. If the initial dose does not provide sufficient benefit and acute side effects are tolerable, the dose may be increased to 60 mg as needed. Never exceed one dose per 24 hours without medical advice.
- Initial dose: 30 mg as needed.
- Possible increase: 60 mg if response is inadequate and medication side effects are acceptable.
- Not intended for routine once daily dosing unless a clinician specifically recommends otherwise for a particular patient.
Secure in computing, storage means the capacity to retain data over time.
- Keep at normal room temperature, away from direct sunlight, heat, and moisture.
- Store out of reach of children and pets in a secure location.
Avoid making use of if
Do not take dapoxetine in the following situations. If any apply, consult a healthcare provider before using this product.
- Known hypersensitivity to dapoxetine or any formulation component.
- You have been advised against sexual activity because of serious heart conditions.
- Concurrent use of nitrates or recreational nitrite products (for example, amyl nitrite).
- Current or recent use of monoamine oxidase inhibitors (MAOIs), linezolid, or MAOI treatment in the prior 14 days.
- Unsupervised use with other serotonergic antidepressants such as SSRIs or SNRIs due to the risk of serotonin syndrome.
If any of these apply, contact your healthcare professional promptly.
Drug and substance the act of connecting with others effects
The following list highlights real time the act of engaging with otherss enable quick problem solving. of importance but is not complete. Always provide your clinician with a full list of prescription, over the counter medicines, and herbal supplements you use.
- Strong CYP3A4 inhibitors (for example, ketoconazole, itraconazole, ritonavir, saquinavir, erythromycin) can raise dapoxetine exposure and increase adverse effect risk.
- CYP3A4 inducers (for example, rifampin, carbamazepine, bosentan) may reduce dapoxetine levels and lower effectiveness.
- Alpha blockers and several antihypertensive agents may increase the chance of symptomatic low blood pressure, dizziness, or syncope.
- Nitrates or nitroprusside must not be combined with dapoxetine because of potentially severe hypotension.
- Other serotonergic agents (SSRIs, SNRIs, triptans, tramadol, Common St Johns wort) raise the risk of serotonin syndrome.
- Drinking alcohol and central nervous system depressants can increase drowsiness and fainting tendencies.
Survey potential social the act of engaging with otherss influence perceptions and decisions. with every healthcare professional involved in your care before starting dapoxetine.
Preventive steps and warning notices
- Spinning sensation, lightheadedness, and fainting have been reported. These are more likely when standing quickly, in hot conditions, or with alcohol intake. Rise slowly from sitting or lying positions and sit or lie down if you feel faint.
- Avoid driving or operating heavy machinery until you know how this medicine affects you.
- People with major cardiac disease should discuss risks with their clinician. Seek emergency help for chest pain, difficulty breathing, severe fainting, or sudden neurologic changes.
- Visual disturbances have been rarely reported; seek medical advice for persistent or severe vision problems.
- Elderly patients may be more sensitive to unintended effects and should use dapoxetine with caution.
- Not indicated for individuals younger than 18 years.
- Dapoxetine does not prevent sexually transmitted infections or pregnancy; use condoms and suitable contraception.
- Prolonged painful erections are a rare but serious adverse event; seek urgent care if an erection lasts longer than four hours.
Potential adverse outcomes
Many users tolerate dapoxetine well, but unwanted reactions can occur. Contact your healthcare provider if you experience severe or concerning symptoms.
Frequent reactions reported include nausea, dizziness, headaches, diarrhea, dry mouth, drowsiness or difficulty sleeping, tremor, anxiety, and fatigue.
With lower frequency but more serious events include fainting, seizures, serotonin syndrome (symptoms can include confusion, high temperature, muscle stiffness, rapid heart rate, and heavy sweating), severe mood changes, or suicidal ideation. If these signs appear, seek medical help immediately.
Other options and similar medications
Based on clinical needs and local approval, clinicians may recommend a second option or adjunctive options. Discuss risks and benefits coordinated with your prescriber.
- Daily SSRIs used off label for premature ejaculation, such as paroxetine, sertraline, and fluoxetine. These agents usually require continuous dosing and take days to weeks to become effective. They are generally inexpensive in generic form.
- Short course or on demand off label agents include clomipramine (a tricyclic antidepressant) and tramadol, although tramadol has dependence risk and is not a first choice for many clinicians.
- Topical anesthetics like lidocaine or prilocaine creams or sprays applied to the glans reduce sensitivity and can delay ejaculation.
- Behavioral techniques and sex therapy: stop start, squeeze method, pelvic floor strengthening exercises, and psychological therapy can be helpful alone or alongside medication.
- When erectile dysfunction is present alongside premature ejaculation, PDE5 inhibitors such as sildenafil, tadalafil, or vardenafil may assist with erections and are often used together with treatments targeting ejaculation.
Watch the manual Pricing in America (approximate) for cost comparisons among these options.
Price ranges in the United States (USD)
Prices are indicative and vary over time and by source. The figures below combine retail pharmacy competitive pricing, discount program values, and recent online observations.
- Dapoxetine (not approved by the FDA in the United States): international online listings often show prices in the range of about 2 to 10 USD per tablet for 30 mg to 60 mg strengths. Purchasing from unverified vendors carries legal and safety risks; see Status in Law and Regulatory Notes.
- Generic SSRIs used off label (paroxetine, sertraline, fluoxetine): typical monthly costs are roughly 4 to 25 USD depending on dose, brand versus generic status, and discount programs.
- Topical lidocaine or lidocaine-prilocaine products: commonly 20 to 60 USD for a 30 to 50 gram tube; sprays are generally 25 to 50 USD per multi dose pack.
- PDE5 inhibitors for erectile dysfunction: generic sildenafil approximately 1 to 5 USD per tablet; generic tadalafil around 2 to 8 USD per tablet depending on dose and quantity.
Insurance plans vary in coverage for off label uses. Verify pharmacy legitimacy, current promotional pricing, and status of legality before purchasing any medication.
Status under law and regulatory notes for policy makers in the USA
- Regulatory position: dapoxetine is not approved by the U.S. Food and Drug Administration and is not available from licensed U.S. pharmacies as an FDA approved product.
- Marketing and sale of unapproved drugs in the United States is unlawful.
- Importation: limited personal importation may be permitted in exceptional circumstances, but customs and FDA can detain or seize shipments. Possession of a foreign prescription does not guarantee importation success.
- Clinical practice: U.S. clinicians commonly use approved medications off label for premature ejaculation, such as daily SSRIs, and may recommend nonpharmacologic strategies that comply with U.S. regulations.
- Consumer safety note: online purchases from unknown sellers risk counterfeit, contaminated, or substandard products. Work with a licensed provider and verified pharmacy sources to guard against risk.
For a treatment plan that follows U.S. law and reduces safety risks, consult a licensed healthcare professional and consider domestically accepted other routes.
See added notes
For practical questions about dosing, positive interactive engagements enhance user satisfaction., or choosing among treatments, see How to Employ This, How Drugs Interact With Substances, and Comparable Medicines and Alternative Therapies, or speak with your clinician or pharmacist.
This document is for informational purposes only and does not replace individualized medical advice. If there is an emergency, contact local emergency services without delay.
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