Concise a compact overview of the section
Sildenafil, commonly supplied as sildenafil citrate, is a medication most often used to treat erectile dysfunction in adult men. It is available in a range of tablet strengths in Australia and has a separate formulation and dosing schedule when prescribed for pulmonary arterial hypertension; do not substitute one formulation for the other without professional advice. Watch the the legal section within the document for supply requirements at Australian Regulations for Legal and Supply.
Typical tablet strengths distributed in Australia include 25 mg, 50 mg and 100 mg. Sildenafil needs sexual stimulation to produce an erection and is not a stimulant for athletic performance; athletes should consult sporting authorities and medical advisors as noted under Safety Alerts and Safety guardrails.
How Sildenafil Targets Erectile Function
Sildenafil supports erectile function by blocking the enzyme phosphodiesterase type 5, or PDE5. During sexual arousal the body releases nitric oxide which raises levels of cyclic GMP in penile tissue, causing smooth muscle relaxation and increased blood flow. By slowing the breakdown of cyclic GMP, sildenafil helps maintain that relaxation and improves the ability to achieve and keep an erection when sexual stimulation is present.
It will not cause an erection on its own without sexual arousal.
Who Should Use Sildenafil
- Adult men diagnosed with erectile dysfunction after assessment by a clinician.
- People treated for pulmonary arterial hypertension should use the specific product and regimen intended for that condition and consult a specialist rather than swapping ED tablets; see Australian Legal and Supply Related Rules for supply notes.
- Sildenafil for ED is not routinely prescribed for women or for individuals under 18 years of age. Consider specialist advice for atypical cases; see Contramanifestations to use in these settings and Avoidance as well.
Dosing and Drug Administration Guidance
The usual starting dose for erectile dysfunction is 50 mg taken about 30 to 60 minutes before anticipated sexual activity. Some users notice effects sooner, sometimes within 15 minutes, along with the clinical effect commonly lasts for up to four hours.
- Based on tolerability and response the dose can be reduced to 25 mg or raised to 100 mg. One dose in a 24 hour period at most.
- A high fat meal may delay absorption and slow the onset of action, so taking sildenafil on an empty stomach can produce a quicker effect in some people.
- Avoid grapefruit products close to dosing because they can increase drug levels.
- Limit alcohol intake on dosing days as alcohol can impair ability to achieve an erection and increase dizziness.
Patients with significant kidney or liver impairment, or those taking alpha-blockers or strong CYP3A4 inhibitors, may be advised to start at a lower dose such as 25 mg. Discuss dose adjustments with your prescriber; see the description of the interacting as a shared activity at Drug Interaction Management and Medication Advice.
Safety Alerts and Steps to prevent harm
Plan before you begin sildenafil tell your prescriber about any allergies to sildenafil or any excipients in the tablet. Inform them about cardiac history, blood pressure problems, eye conditions and any history of prolonged erections.
- Older adults may be more sensitive to low blood pressure, dizziness and changes in vision.
- Seek specialist input if you have structural penile problems, bleeding disorders, active gastric ulcers, retinitis pigmentosa, or a prior episode of priapism.
- If you experience chest pain during sexual activity stop and request urgent medical attention.
- Immediate medical review is required for sudden changes in vision or hearing.
Sporting note: sildenafil is not currently on the World Anti-Doping Agency prohibited list but regulations can change. Athletes should check the latest guidance from Sport Integrity Australia and consult a sports physician before use. See also related links supply rules at Australian Rules for Legal and Supply.
Reasons to avoid use and Avoidance
Do not use sildenafil if any of the following apply to you:
- You are taking nitrate medications such as glyceryl trinitrate or isosorbide mononitrate, or you use recreational nitrites commonly called poppers. Combining these with sildenafil can cause a dangerous fall in blood pressure.
- You are using riociguat or other stimulators of soluble guanylate cyclase.
- You are concurrently taking another erectile dysfunction medication unless under direct clinical supervision.
- You have recently had a major heart event, or a clinician has advised you to avoid sexual activity for cardiac reasons.
- There is a history of non-arteritic anterior ischemic optic neuropathy with suspected link to PDE5 inhibitors.
- You are under 18 years of age for the ED indication, or you are a woman seeking ED treatment without specialist oversight.
Undesired effects and Signs to Watch
Most users have a favorable tolerability profile with sildenafil. Average and mild reactions include:
- Cranial ache that is accompanied by facial flushing
- Stomach discomfort, heartburn or dyspepsia
- Nasal blockage
- Lightheadedness with dizziness
- Passing loose stools or diarrhoea
Scarcely seen but clinically important reactions:
- Visual changes such as a blue tinge, blurred sight or increased sensitivity to light
- Pain in the back or stiffness of the muscles
- Rash localized to the skines
Pursue urgent medical care for chest pain, fainting, a painful erection lasting longer than four hours, sudden loss of vision or sudden hearing loss. For advice on accidental excess intake consult An opioid overdose of medicine and First Aid in Emergencies or contact your local Poisons Information Centre.
Potential Interpersonal engagements Between Drugs and Medication Advice
Certain medicines must not be combined with sildenafil and others require careful dose planning. Always provide a complete list of prescription, over the counter and complementary medicines to your prescriber or pharmacist.
- Absolute avoid: nitrates and recreational nitrites.
- Avoid use with riociguat and similar agents.
- Use caution when combining with alpha-blockers such as doxazosin or tamsulosin because of additive blood pressure effects.
- Strong CYP3A4 inhibitors like ritonavir, cobicistat, ketoconazole, itraconazole and clarithromycin can raise sildenafil levels and may require dose reduction.
- Grapefruit products can increase exposure and should be avoided near dosing.
- Concomitant antihypertensive drugs and alcohol can enhance hypotensive effects.
Routine Use and You forgot to take your doses
For erectile dysfunction sildenafil is taken as needed, so there is no regular daily schedule and no the dose was missed procedure as for daily medicines. The pulmonary arterial hypertension form follows a regular schedule set by the prescriber; do not double up after a the dose was missed without clinical instruction.
Never exceed one dose in a 24 hour period. Repeated or frequent dosing above recommended amounts increases the risk of undesired consequences.
Handling OD and Emergency Medical Aid Situations
If you suspect an overdosing seek immediate emergency assistance or contact your local Poisons Information Centre. Symptoms that may indicate overdosing include severe dizziness, fainting, chest pain, irregular heartbeat, persistent nausea, marked visual disturbance or a sustained and painful erection. Prompt assessment is essential if severe symptoms occur.
Stowage and Handling Guidelines Tips
- Store at room temperature, about 20 to 25 degrees Celsius.
- Keep tablets in their original blister pack or container to protect from moisture and strong light.
- Avoid storing in bathrooms or other humid areas.
- Ensure that children and pets cannot reach or see this.
Feasible variant options and Therapeutic Comparison
Other PDE5 inhibitors and management approaches may suit different needs. Choice depends on desired onset, duration, side effect profile, the back and forth between peoples are the heartbeat of social platforms. and cost. Talk with your doctor about the options.
- Tadalafil (for example Cialis) tends to last much longer, often up to 36 hours, and is available in daily low dose regimens for some patients.
- Vardenafil (for example Levitra) has a similar duration to sildenafil and some formulations are orodispersible.
- Avanafil (for example Spedra) can have a quicker onset for some users and may work in about 15 minutes.
- Generic sildenafil contains the same active ingredient as brand Viagra and is generally less expensive per tablet.
Non pharmacological strategies include weight reduction, smoking cessation, optimized control of diabetes and blood pressure, psychological therapies, vacuum erection devices and referral to urology for structural or refractory problems. For cost and price evaluation and comparison see Prices and Cost Comparison (AUD).
Prices and Cost Comparison (AUD)
Costs vary by brand, strength, pack size alongside the pharmacy. The figures below are approximate private prices seen in Australian community pharmacies and reputable online pharmacies and are given in Australian dollar amounts.
- Generic sildenafil 100 mg: roughly AUD 1.50 to AUD 4.00 per tablet depending on pack size and discounting.
- Brand Viagra 100 mg: roughly AUD 15 to AUD 30 per tablet when purchased privately.
- Generic tadalafil 20 mg: roughly AUD 2.00 to AUD 6.00 per tablet.
- Brand Cialis 20 mg: roughly AUD 15 to AUD 25 per tablet.
- Vardenafil 20 mg (brand or generic): roughly AUD 10 to AUD 20 per tablet.
- Avanafil 200 mg (Spedra): roughly AUD 15 to AUD 30 per tablet.
Most medicines for erectile dysfunction are not subsidised under the Pharmaceutical Benefits Scheme for this indication, so expect to pay privately unless you have a specific concessional arrangement. Ask your pharmacist about generic versions, larger pack discounts and any additional dispensing fees that will affect the final price.
Australian Legal and Supply Regulations
Key regulatory points to be aware of in Australia:
- Scheduling: Sildenafil for erectile dysfunction is a prescription only medicine classified as Schedule 4 under the Poisons Standard, so a valid prescription is required.
- Supply: You must obtain a lawful prescription from an Australian registered prescriber to collect sildenafil from an Australian pharmacy. Telehealth prescribing is acceptable provided it complies with current regulatory directional support.
- Advertising: Direct to consumer advertising of prescription medicines is restricted by the Therapeutic Goods Act and associated advertising codes.
- Personal importation: Importing medicines for personal use may be possible for limited supplies if you have an appropriate prescription alongside the product complies with Therapeutic Goods Administrative guidance, but customs and biosecurity requirements still apply.
- Sporting considerations: Sildenafil is not currently a banned substance under WADA but athletes should confirm current status with Sport Integrity Australia before operating.
Obtain medicines through legal, regulated channels and follow your prescribers directions. For additional support and links see Further Notes and Reference Resources.
Further Notes, Resources, and List of references
For tailored advice consult your doctor, specialist or pharmacist. Topics to review with them include:
- Your full medical history and current list of medications and supplements
- Which initial dose is appropriate and how to adjust safely
- Cost options, generic more options and any pharmacy dispensing fees
- When to seek urgent care for adverse reactions
Quick internal references: summary at Quick synopsis of the a broad strokes summary, practical dosing at Dose Administration Protocols Guidance, and legal requirements at Australian Legal and Supply Chain Regulations.
- Synthroid Explained: Uses, Medication drug side effects, and Beyond
- Nolvadex: eligibility and safety profile
- Exploring Furosemide: is it FDA approved?
- Buspar: A Review of Negative effects and Bodily Impacts
- Who should be considered for Augmentin and who should not